Key Publications (from > 240 total)
1. The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules. Gartner, Z. J. and Liu, D. R. J. Am. Chem. Soc. 123, 6961-6963 (2001). PDF
2. DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. Science 305, 1601-1605 (2004). PDF
3. Reaction Discovery Enabled by DNA-Templated Synthesis and In Vitro Selection. Kanan, M. W.; Rozenman, M. M.; Sakurai, K.; Snyder, T. M., Liu, D. R. Nature 431, 545-549 (2004). PDF
4. A System for the Continuous Directed Evolution of Biomolecules. Esvelt, K. M.; Carlson, J. C.; Liu, D. R. Nature 472, 499–503 (2011). PDF
5. Experimental Interrogation of the Path Dependence and Stochasticity of Protein Evolution Using Phage-Assisted Continuous Evolution. Dickinson, B. C.; Leconte, A. M.; Allen, B.; Esvelt, K. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 110, 9007-9012 (2013). PDF
6. Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones. Maianti, J. P.; McFedries, A.; Foda, Z. H.; Kleiner, R. E.; Du, X.-Q.; Leissring, M. A.; Tang, W.-J.; Charron, M. J.; Seeliger, M. A.; Saghatelian, A.; Liu, D. R. Nature 511, 94-98 (2014). PDF
7. Continuous Evolution of B. thuringiensis Toxins Overcomes Insect Resistance. Badran, A. H.; Guzov, V. M.; Huai, Q.; Kemp, M. M.; Vishwanath, P.; Kain, W.; Evdokimov, A.; Moshiri, F.; Turner, K. H.; Wang, P.; Malvar, T.; Liu, D. R. Nature 533, 58-63 (2016). PDF
8. Programmable Editing of a Target Base in Genomic DNA Without Double-Stranded DNA Cleavage. Komor, A. C.; Kim, Y. B.; Packer, M. S.; Zuris, J. A.; Liu, D. R. Nature 533, 420-424 (2016). PDF
9. Programmable Base Editing of A•T to G•C in Genomic DNA Without DNA Cleavage. Gaudelli, N. M.; Komor, A. C.; Rees, H. A.; Packer, M. S.; Badran, A. H.; Bryson, D. I.; Liu, D. R. Nature 551, 464-471 (2017). PDF
10. Treatment of Autosomal Dominant Hearing Loss by In Vivo Delivery of Genome Editing Agents. Gao, X.; Lamas, V.; Huang, M.; Yeh, W.-H.; Pan, B.; Hu, Y.-J.; Hu, J. H.; Thompson, D. B.; Shu, Y.; Li, Y.; Wang, H.; Yang, S.; Xu, Q.; Polley, D. B.; Liberman, M. C.; Kong, W.-J.; Holt, J. R.; Chen, Z.-Y.; Liu, D. R. Nature 553, 217-221 (2018). PDF
11. Evolved Cas9 Variants with Broad PAM Compatibility and High DNA Specificity. Hu, J. H.; Miller, S. M.; Geurts, M. H.; Tang, W.; Chen, L.; Sun, N.; Zeina, C.; Gao, X.; Rees. H. A.; Lin, Z.; Liu, D. R. Nature 556, 57-63 (2018). PDF
12. Search-and-replace genome editing without double-strand breaks or donor DNA. Anzalone, A.V.; Randolph, P.B.; Davis, J.R.; Sousa, A.A.; Koblan, L.W.; Levy, J.M.; Chen, P.J.; Wilson, C.; Newby, G.A.; Raguram, A.; Liu, D.R. Nature, 576, 149–157 (2019). PDF SI
13. An interbacterial cytidine deaminase toxin enables mitochondrial base editing. Mok, B. Y; de Moraes, M. H; Zeng, J; Bosch, D. E; Kotrys, A. V; Raguram, A.; Hsu, F; Radey, M.C; Broko Peterson, B; Mootha, V.K; Mougous, J.D; Liu, D. R. Nature. 583, 631-637 (2020). PDF SI
14. Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning Arbab, M.; Shen, M. W.; Mok, B.; Wilson, C.; Matuszek, Z.; Cassa, C. A.; Liu, D. R. Cell. 182, 463-480 (2020). PDF SI
15. In Vivo Adenine Base Editing Corrects Hutchinson-Gilford Progeria Syndrome. Koblan L. W.; Erdos, M. R.; Wilson, C.; Cabral, W. A.; Levy, J. M.; Xiong, Z.-M.; Taarez, U. L.; Davison, L.; Gete, Y. G.; Mao, X.; Newby, G. A.; Doherty, S. P.; Lin, C. Y.; Gordon, L. B.; Cao, K.; Collins, F. S.; Brown, J. D.; Liu, D. R. Nature 589, 608-614 (2021). PDF SI “Base Editing in Progeria” NEJM Companion Paper
16. Phage-Assisted Evolution of Selective Botulinum Neurotoxin Proteases with Reprogrammed Substrate Specificity. Blum, T. R.; Liu, H.; Packer, M. S.; Xiong, X.; Lee, P.-G.; Zhang, S.; Richter, M.; Dong, M.; Liu, D. R. Science 371, 803-810 (2021) PDF SI Insights:Perspectives
17. Base Editing of Hematopoietic Stem Cells Rescues Sickle Cell Disease in Mice. Newby, G. A.; Yen. J. S.; Woodard, K. J.; Mayuranathan, T.; Lazzarotto, C. R.; Li, Y.; Sheppand-Tillman, H.; Porter, S. N.; Yao, Y.; Mayberry, K.; Everette, K. A.; Jang, Y.; Podracky, C. J.; Thaman, E.; Lechauve, C.; Sharma, A; Henderson, J. M.; Richter, M. F.; Zhao, K. T.; Miller, S. M.; Wang, T.; Koblan, L. W.; McCaffrey, A. P.; Tisdale, J. F.; Kalfa, T. A.; Pruett-Miller, S. M.; Tsai, S. Q.; Weiss, M. J.; Liu, D. R. Nature 595, 295-302 (2021). PDF SI
18. Enhanced Prime Editing Systems by Manipulating Cellular Determinants of Editing Outcomes.Chen. P. J.; Hussmann, J. A.; Yan, J.; Knipping, D.; Ravisankar, P.; Chen, P.-F.; Chen, C.; Nelson, J. W.; Newby G. A.; Sahin, M.; Osborn, M. J.; Weissman, J. S.; Adamson, B.; Liu, D. R.Cell. 22, 5635–5652 (2021). PDF SI
19. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Banskota, S.; Raguram, A.; Suh, S.; Du, S.W.; Davis, J.R.; Choi, E.H. Wang, X.; Nielsen, S.C.; Newby, G.A.; Randolph, P.B.; Osborn, M.J.; Musunuru, K.; Palczewski, K.; Liu, D. R. Cell. 185, 250-265. (2022). PDF
20. Base Editing Rescue of Spinal Muscular Atrophy in Cells and in Mice. Arbab, M. Matuszek, Z.; Kray, K. M.; Du, A.; Newby, G. A.; Blatnik, A. J.; Raguram, A.; Richter, M. F.; Zhao, K. T.; Levy, J. M.; Shen. M. W.; Arnold, W. D.; Wang, D. ; Xie, J.; Gao, G.; Burghes, A. H. M.; Liu, D. R. Science 380 [6642], available online (2023). PDF | SI | [Videos]
21. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Doman, J.*; Pandey, S.*; Neugebauer, M.E.; An, M.; Davis, J.R.; Randolph, P.B.; McElroy, A.; Gao, X.D.; Raguram, A.; Richter, M.F.; Everette, K.A.; Banskota, S.; Tian, K.; Tao, A.Y.; Tolar, J.; Osborn, M.J.; Liu, D.R. Cell, 186(18): 3983-4002 (2023). PDF
22. Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Cereblon Molecular Glues. Mercer, J. A. M.; DeCarlo, S. J.; Burman, S. S. R.; Sreekanth, V.; Nelson, A. T.; Hunkeler, M.; Chen. P. J.; Donovan, K. A.; Kokkonda, P.; Tiwari, P.; Shoba, V. M.; Deb. A.; Choudhary, A.; Fischer, E. S.; Liu, D.R. Science in press, online (2024). PDF | SI